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Phenotypes Associated with This Genotype
Genotype
MGI:2661972
Allelic
Composition
Ncf1m1J/Ncf1m1J
Genetic
Background
B6.Cg-Dock7m +/+ Leprdb/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncf1m1J mutation (3 available); any Ncf1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peritoneal neutrophils, bone marrow cells and neutrophils isolated from bone marrow fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)
• peritoneal macrophages fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)
• following exposure to inactivated H5N1 virus , acute-lung injury is attenuated compared to in wild-type mice

hematopoietic system
• peritoneal neutrophils, bone marrow cells and neutrophils isolated from bone marrow fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)
• peritoneal macrophages fail to produce superoxide upon stimulation in vitro with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic granulomatous disease DOID:3265 OMIM:PS306400
J:83428


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory