Phenotypes Associated with This Genotype

Genotype
MGI:2661094

• Allelic Composition: Grk6^tm1.1Mca/Grk6⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:83191 )

• mutants exhibit supersensitivity to psychostimulants, showing increased horizontal movement in response to amphetamine and beta-phenylethylamine relative to wild-type

• supersensitivity is due to increased responsiveness of postsynaptic dopamine receptors

enhanced behavioral response to cocaine ( J:83191 )

• increased horizontal behavior in response to cocaine relative to wild-type

increased locomotor activity ( J:83191 )

• increased horizontal movement in response to cocaine, amphetamine, and beta-phenylethylamine relative to wild-type littermates