Phenotypes Associated with This Genotype

Genotype
MGI:2661057

• Allelic Composition: Ripk2^tm1Flv/Ripk2^tm1Flv
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:75400 )

• reduced proliferation of thymocytes after Il-1beta stimulation

abnormal T-helper 1 physiology ( J:75400 )

• IFN-gamma production by T helper 1 cells reduced

• IFN-gamma production severely reduced after stimulation with either Il-18 or Il-12

abnormal cytokine secretion ( J:75400 )

decreased interleukin-6 secretion ( J:75400 )

• production by macrophages severely reduced after stimulation by ligands for some but not all Toll-like receptors

• production by thymocytes also reduced when stimulated by Il-1beta

decreased tumor necrosis factor secretion ( J:75400 )

• production by macrophages severely reduced after stimulation by ligands for some but not all Toll-like receptors

hematopoietic system

decreased T cell proliferation ( J:75400 )

• reduced proliferation of thymocytes after Il-1beta stimulation

abnormal T-helper 1 physiology ( J:75400 )

• IFN-gamma production severely reduced after stimulation with either Il-18 or Il-12

• IFN-gamma production by T helper 1 cells reduced

cellular

decreased T cell proliferation ( J:75400 )

• reduced proliferation of thymocytes after Il-1beta stimulation