Phenotypes Associated with This Genotype

Genotype
MGI:2660695

• Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

decreased susceptibility to bacterial infection ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

abnormal susceptibility to Orthomyxoviridae infection ( J:107677 )

• influenza viral titers are higher in mutants at day 3, 6 and 7 post infection compared to wild-type, however by day 21 post infection, no virus is detected, indicating a delay in T cell-dependent viral clearance

decreased susceptibility to Orthomyxoviridae infection ( J:107677 )

• reduced pneumonitis after infection with influenza virus

decreased susceptibility to Picornaviridae infection ( J:28704 )

• resistance to Coxsackie virus-induced myocarditis

digestive/alimentary system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice