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Phenotypes Associated with This Genotype
Genotype
MGI:2658931
Allelic
Composition
Sptbja/Sptbja
Genetic
Background
129/Sv-Sptbja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbja mutation (2 available); any Sptb mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die within a day or two of birth, but a few survive to adulthood
• incomplete penetrance

cardiovascular system
• evident at E15

hematopoietic system
• evident as early as E15; about half the normal number of red cells are present
• there is considerable erythrocyte destruction and a compensating release of immature blood cells into the circulation
• spectrin does not accumulate in the reticulocyte plasma membrane
• evident at E15

immune system
• evident at E15

liver/biliary system
• evident at P2
• evident at P2
• developed within hours after birth

Mouse Models of Human Disease
OMIM ID Ref(s)
Spectrin, Beta, Erythrocytic; SPTB 182870 J:305 , J:7501 , J:44313


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory