Phenotypes Associated with This Genotype

Genotype
MGI:2658931

• Allelic Composition: Sptb^ja/Sptb^ja
• Genetic Background: 129/Sv-Sptb^ja

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:7501 )

• most homozygotes die within a day or two of birth, but a few survive to adulthood

prenatal lethality, incomplete penetrance ( J:305 )

• incomplete penetrance

cardiovascular system

enlarged heart ( J:305 )

• evident at E15

hematopoietic system

enlarged spleen ( J:305 )

• evident at E15

hemolytic anemia ( J:305 )

• evident as early as E15; about half the normal number of red cells are present

• there is considerable erythrocyte destruction and a compensating release of immature blood cells into the circulation

anisocytosis ( J:305 )

poikilocytosis ( J:305 )

abnormal reticulocyte morphology ( J:7501 )

• spectrin does not accumulate in the reticulocyte plasma membrane

reticulocytosis ( J:305 )

immune system

enlarged spleen ( J:305 )

• evident at E15

liver/biliary system

enlarged liver ( J:305 )

• evident at P2

multifocal hepatic necrosis ( J:305 )

• evident at P2

jaundice ( J:305 )

• developed within hours after birth

growth/size/body

enlarged heart ( J:305 )

• evident at E15

enlarged liver ( J:305 )

• evident at P2

enlarged spleen ( J:305 )

• evident at E15