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Phenotypes Associated with This Genotype
Genotype
MGI:2658931
Allelic
Composition
Sptbja/Sptbja
Genetic
Background
129/Sv-Sptbja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbja mutation (2 available); any Sptb mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die within a day or two of birth, but a few survive to adulthood (J:7501)
• most homozygotes die within a day or two of birth, but a few survive to adulthood (J:7501)
• incomplete penetrance (J:305)
• incomplete penetrance (J:305)

cardiovascular system
• evident at E15 (J:305)
• evident at E15 (J:305)

hematopoietic system
• evident as early as E15; about half the normal number of red cells are present (J:305)
• there is considerable erythrocyte destruction and a compensating release of immature blood cells into the circulation (J:305)
• evident as early as E15; about half the normal number of red cells are present (J:305)
• there is considerable erythrocyte destruction and a compensating release of immature blood cells into the circulation (J:305)
• spectrin does not accumulate in the reticulocyte plasma membrane (J:7501)
• spectrin does not accumulate in the reticulocyte plasma membrane (J:7501)
• evident at E15 (J:305)
• evident at E15 (J:305)

immune system
• evident at E15 (J:305)
• evident at E15 (J:305)

liver/biliary system
• evident at P2 (J:305)
• evident at P2 (J:305)
• evident at P2 (J:305)
• evident at P2 (J:305)
• developed within hours after birth (J:305)
• developed within hours after birth (J:305)

Mouse Models of Human Disease
OMIM ID Ref(s)
Spectrin, Beta, Erythrocytic; SPTB 182870 J:305 , J:7501 , J:44313


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory