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Phenotypes Associated with This Genotype
Genotype
MGI:2657283
Allelic
Composition
Zic3Bn/Zic3Bn
Genetic
Background
BNT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3Bn mutation (2 available); any Zic3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
(J:13124)
(J:14983)
• approximately 1/4 of animals are lost due to early lethality

craniofacial
• the skull is slightly wider than normal
• interfrontal bone is often present
• variable penetrance (J:5776)
(J:63168)

growth/size/body
• in the most severely affected animals
• abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females

limbs/digits/tail
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female
(J:13124)
(J:14983)
(J:62608)
(J:63168)
(J:13124)
(J:14983)
(J:62608)
(J:63168)

reproductive system
• number of affected offspring is lower than expected (J:13124)
(J:14983)
(J:63168)

skeleton
• the skull is slightly wider than normal
• interfrontal bone is often present
• variable penetrance (J:5776)
(J:63168)
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female

nervous system
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)
• variable penetrance (J:5776)
(J:63168)

embryo
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory