Mouse Genome Informatics
hm
    Zic3Bn/Zic3Bn
BNT/LeJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
(J:13124)
(J:14983)
• approximately 1/4 of animals are lost due to early lethality (J:63168)

craniofacial
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• variable penetrance (J:5776)
(J:63168)

growth/size/body
• in the most severely affected animals (J:63168)
• abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females (J:62608)

limbs/digits/tail
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)
(J:13124)
(J:14983)
(J:62608)
(J:63168)
(J:13124)
(J:14983)
(J:62608)
(J:63168)

reproductive system
• number of affected offspring is lower than expected (J:13124)
(J:14983)
(J:63168)

skeleton
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• variable penetrance (J:5776)
(J:63168)
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)

nervous system
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)
• variable penetrance (J:5776)
(J:63168)

embryogenesis
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)

Mouse Models of Human Disease
OMIM IDRef(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:5776 , J:13124 , J:14983 , J:62608 , J:63168