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Phenotypes Associated with This Genotype
Genotype
MGI:2657283
Allelic
Composition
Zic3Bn/Zic3Bn
Genetic
Background
BNT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3Bn mutation (2 available); any Zic3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
(J:13124)
(J:13124)
(J:14983)
(J:14983)
• approximately 1/4 of animals are lost due to early lethality (J:63168)
• approximately 1/4 of animals are lost due to early lethality (J:63168)

craniofacial
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• variable penetrance (J:5776)
• variable penetrance (J:5776)
(J:63168)
(J:63168)

growth/size/body
• in the most severely affected animals (J:63168)
• in the most severely affected animals (J:63168)
• abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females (J:62608)
• abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females (J:62608)

limbs/digits/tail
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)
(J:13124)
(J:13124)
(J:14983)
(J:14983)
(J:62608)
(J:62608)
(J:63168)
(J:63168)
(J:13124)
(J:13124)
(J:14983)
(J:14983)
(J:62608)
(J:62608)
(J:63168)
(J:63168)

reproductive system
• number of affected offspring is lower than expected (J:13124)
• number of affected offspring is lower than expected (J:13124)
(J:14983)
(J:14983)
(J:63168)
(J:63168)

skeleton
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• interfrontal bone is often present and the skull is slightly wider than normal (J:5776)
• variable penetrance (J:5776)
• variable penetrance (J:5776)
(J:63168)
(J:63168)
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)
• fewer and smaller caudal vertebrae than normal; more severe than heterozygous female (J:63168)

nervous system
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)
(J:63168)
• variable penetrance (J:5776)
• variable penetrance (J:5776)
(J:63168)
(J:63168)

embryogenesis
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
• variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)
(J:63168)
(J:63168)

Mouse Models of Human Disease
OMIM ID Ref(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:5776 , J:13124 , J:14983 , J:62608 , J:63168


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory