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Phenotypes Associated with This Genotype
Genotype
MGI:2656901
Allelic
Composition
Kif5atm1Gsn/Kif5atm1Gsn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5atm1Gsn mutation (1 available); any Kif5a mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all homozygotes born naturally die immediately after birth
• all homozygotes delivered by caesarian section are alive at E18.5 but usually die within 10 min after birth

homeostasis/metabolism
• all homozygotes recovered by caesarian section gradually become cyanotic after birth

respiratory system
• all homozygotes recovered by caesarian section exhibit an abnormal breathing pattern but are otherwise normal relative to wild-type littermates
• mutant lungs fail to expand properly
• however, the neuromuscular junction region and the diaphragm appear unaffected

nervous system
N
• homozygotes display normal cortex, hippocampus, and cerebellum histology relative to wild-type mice
• in culture, mutant hippocampal neurons appear morphologically and electrophysiologically normal with no apparent defects in synaptic transmission
• homozygotes exhibit enlarged nuclei and cell bodies of spinal cord motor neurons relative to wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory