Analysis Tools
mortality/aging
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• 50% of embryos die around E7.5
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growth/size/body
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• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
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embryo
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• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
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• ~ 90% of embryos at E7.5 have excessive folds at the cranial limiting furrow region
• the cranial limiting furrow region contains more than two cell layers and is disorganized
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• embryos are developmentally delayed by about 6 hours at E7.5 and sometimes up to 12 hours or more at E8
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• visceral endoderm accumulates at the cranial limiting furrow of E7.5 mutants
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cardiovascular system
hemorrhage
(
J:82844
)
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• 62% of embryos are hemorrhagic at E7.5
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cellular
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• visceral endoderm cell migration at the anterior embryonic/extra-embryonic junction is abnormal; although distal-to-proximal migration is observed, the lateral migration of cells is greatly reduced
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