growth/size/body
• following a growth arrest of 2-4 days during weaning, heterozygotes resume normal growth but remain 2.5 g lighter than wild-type littermates for at least up to 10 months of age
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• Background Sensitivity: heterozygotes of the inbred colony grow slower than outbred (129P2/OlaHsd x C57BL/6J) heterozygotes
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• between P6 and P21, the body weight of male heterozygotes increases by 0.23 g/d compared with 0.40 g/d in wild-type males
• weaning causes a growth arrest for 2 to 4 days; thereafter, heterozygotes grow as fast as wild-type mice although heterozygous females grow slower than males
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hematopoietic system
• at 5-7 weeks of age, heterozygotes show a 20% reduction in the number of CD4+ single-positive T cells in the thymus relative to wild-type mice
• however, the total number of lymphocytes in spleen and thymus is unaffected
• no abnormalities are detected in splenocytes or in the tissue architecture of thymus and spleen
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immune system
• at 5-7 weeks of age, heterozygotes show a 20% reduction in the number of CD4+ single-positive T cells in the thymus relative to wild-type mice
• however, the total number of lymphocytes in spleen and thymus is unaffected
• no abnormalities are detected in splenocytes or in the tissue architecture of thymus and spleen
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