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Phenotypes Associated with This Genotype
Genotype
MGI:2655238
Allelic
Composition
Grin1tm2Slab/Grin1tm1.1Slab
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Slab mutation (0 available); any Grin1 mutation (64 available)
Grin1tm2Slab mutation (2 available); any Grin1 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice died within 1 hour of birth

homeostasis/metabolism

respiratory system

nervous system
• absence of whisker-related patterning in the brainstem trigeminal complex
• however, no difference is seen between external brain morphology or weight relative to control mice
• absence of patterned synapses of trigeminal afferents and their target cells (barrelettes)
• normal topographic mapping of primary trigeminal afferents
• NMDA receptors are functional but lack coincidence detection properties


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory