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Phenotypes Associated with This Genotype
Genotype
MGI:2655194
Allelic
Composition
Il2rgtm1Sug/Y
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Sug mutation (6 available); any Il2rg mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• arrested B cell development after the pro-B cell stage
• increased numbers of myelocyte blast cells in spleen and peripheral blood
• increased numbers of erythroid blast cells in spleen and peripheral blood
• increased numbers of neutrophil blast cells in spleen and peripheral blood
• reduced lymphocyte numbers in the bone marrow
• decreased total peripheral blood lymphocyte number
• absence of NK cells
• increased numbers of monocytes/macrophages in spleen and peripheral blood
• increased numbers of monocytes/macrophages in spleen and peripheral blood
• reduced numbers of CD45R+/IgM+ cells
• increased numbers of F4/80+ cells
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks
• decreased IgG and IgG3 serum levels

immune system
• arrested B cell development after the pro-B cell stage
• increased numbers of myelocyte blast cells in spleen and peripheral blood
• increased numbers of neutrophil blast cells in spleen and peripheral blood
• reduced lymphocyte numbers in the bone marrow
• decreased total peripheral blood lymphocyte number
• absence of NK cells
• increased numbers of monocytes/macrophages in spleen and peripheral blood
• increased numbers of monocytes/macrophages in spleen and peripheral blood
• reduced numbers of CD45R+/IgM+ cells
• increased numbers of F4/80+ cells
• small, barely detectable, peripheral lymph nodes
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks
• decreased IgG and IgG3 serum levels

endocrine/exocrine glands


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory