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Phenotypes Associated with This Genotype
Genotype
MGI:2655194
Allelic
Composition
Il2rgtm1Sug/Y
Genetic
Background
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Sug mutation (4 available); any Il2rg mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
• arrested B cell development after the pro-B cell stage (J:31167)
• arrested B cell development after the pro-B cell stage (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
• increased numbers of erythroid blast cells in spleen and peripheral blood (J:31167)
• increased numbers of erythroid blast cells in spleen and peripheral blood (J:31167)
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• absence of NK cells (J:31167)
• absence of NK cells (J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)
(J:31167)
(J:31167)

immune system
• arrested B cell development after the pro-B cell stage (J:31167)
• arrested B cell development after the pro-B cell stage (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• absence of NK cells (J:31167)
• absence of NK cells (J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
(J:31167)
(J:31167)
• small, barely detectable, peripheral lymph nodes (J:31167)
• small, barely detectable, peripheral lymph nodes (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)
(J:31167)
(J:31167)

endocrine/exocrine glands
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)
(J:31167)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory