Mouse Genome Informatics
ot
    Il2rgtm1Sug/Y
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
(J:31167)
• increased numbers of erythroid blast cells in spleen and peripheral blood (J:31167)
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• absence of NK cells (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• arrested B cell development after the pro-B cell stage (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
(J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)

immune system
• increased numbers of neutrophil blast cells in spleen and peripheral blood (J:31167)
• reduced lymphocyte numbers in the bone marrow (J:31167)
• decreased total peripheral blood lymphocyte number (J:31167)
• absence of NK cells (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• increased numbers of monocytes/macrophages in spleen and peripheral blood (J:31167)
• arrested B cell development after the pro-B cell stage (J:31167)
• increased numbers of myelocyte blast cells in spleen and peripheral blood (J:31167)
(J:31167)
(J:31167)
• reduced numbers of CD45R+/IgM+ cells (J:31167)
• increased numbers of F4/80+ cells (J:31167)
• small, barely detectable, peripheral lymph nodes (J:31167)
• increased IgM serum levels at 8 weeks, but decreased at 10-11 weeks (J:31167)
• decreased IgG and IgG3 serum levels (J:31167)

endocrine/exocrine glands
(J:31167)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Combined Immunodeficiency, X-Linked; CIDX 312863 J:31167
NOT Severe Combined Immunodeficiency, X-Linked; SCIDX1 300400 J:31167