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Phenotypes Associated with This Genotype
Genotype
MGI:2655192
Allelic
Composition
Slc1a1tm1Wst/Slc1a1tm1Wst
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a1tm1Wst mutation (0 available); any Slc1a1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• there were no obvious neurological disorders in the first 12 months of life
• learning was not affected as indicated by a water maze test
• motor coordination was normal
• only about half normal level of motor activity
• shorter bursts of activity and longer stretches of inactivity

homeostasis/metabolism
• although plasma amino acid levels are normal, excretion of glutamate is increased 1400X and excretion of aspartate is increased 10X

renal/urinary system
• although plasma amino acid levels are normal, excretion of glutamate is increased 1400X and excretion of aspartate is increased 10X

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dicarboxylic aminoaciduria DOID:0060650 OMIM:222730
J:41613


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory