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Phenotypes Associated with This Genotype
Genotype
MGI:2655192
Allelic
Composition
Slc1a1tm1Wst/Slc1a1tm1Wst
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a1tm1Wst mutation (0 available); any Slc1a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• there were no obvious neurological disorders in the first 12 months of life
• learning was not affected as indicated by a water maze test
• motor coordination was normal
• only about half normal level of motor activity
• shorter bursts of activity and longer stretches of inactivity

homeostasis/metabolism
• although plasma amino acid levels are normal, excretion of glutamate is increased 1400X and excretion of aspartate is increased 10X

renal/urinary system
• although plasma amino acid levels are normal, excretion of glutamate is increased 1400X and excretion of aspartate is increased 10X

Mouse Models of Human Disease
OMIM ID Ref(s)
Dicarboxylic Aminoaciduria; DCBXA 222730 J:41613


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory