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Phenotypes Associated with This Genotype
Genotype
MGI:2654874
Allelic
Composition
Alas2tm1Mym/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alas2tm1Mym mutation (0 available); any Alas2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• arrested primitive hematopoiesis
• erythroid differentiation is arrested
• embryos are severely anemic at E11
• number of circulating blood cells is decreased in E10.5 mutants

embryo
• arrested primitive hematopoiesis
• erythroid differentiation is arrested

homeostasis/metabolism
• severe accumulation of iron in the cytoplasm of circulating blood cells of E9.5 and E10.5 mutants

integument
• embryos are pale at E11.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory