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Phenotypes Associated with This Genotype
Genotype
MGI:2654752
Allelic
Composition
Adam2tm1Dgm/Adam2tm1Dgm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam2tm1Dgm mutation (1 available); any Adam2 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal
• fertility rate is 2% compared to wild-type
• the ability of sperm from mutant mice to bind to and fuse with the egg plasma membrane is reduced
• once fused, egg activation proceeds normally
• sperm are unable to adhere to the zona pellucida

cellular
• migration of sperm from the uterus into the oviduct is impaired
• sperm count and motility are otherwise normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory