Phenotypes Associated with This Genotype

Genotype
MGI:2654495

• Allelic Composition: Tg(Edn1-NOS3)22Yky/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypotension ( J:81132 )

• males exhibit lower systemic arterial pressure

• however, no difference in heart rate

abnormal blood vessel physiology ( J:81132 )

• decrease in basal tone of the aorta

• aortas exhibit an increase in basal cGMP levels and nitric oxide release

decreased vasodilation ( J:81132 )

• aortas exhibit a reduced vasorelaxant response to nitric oxide-mediated vasodilators

homeostasis/metabolism

abnormal blood homeostasis ( J:81132 )

• plasma nitrite and nitrate levels are higher in males than control males

muscle

decreased vasodilation ( J:81132 )

• aortas exhibit a reduced vasorelaxant response to nitric oxide-mediated vasodilators