Phenotypes Associated with This Genotype

Genotype
MGI:2653477

• Allelic Composition: Ski^tm1Cco/Ski⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:73349 )

• n addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased succeptibility for tumors when injected IP with 9,10-dimethyl-1,2-benzanthracene

increased lymphoma incidence ( J:73349 )

• the most frequent tumors to develop were malignant lymphomas

cellular

increased fibroblast proliferation ( J:73349 )

• In addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased rate of proliferation for MEF in culture

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:73349 )

• n addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased succeptibility for tumors when injected IP with 9,10-dimethyl-1,2-benzanthracene