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Phenotypes Associated with This Genotype
Genotype
MGI:2653055
Allelic
Composition
Ndntm2Stw/Ndn+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndntm2Stw mutation (1 available); any Ndn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice inheriting the mutant allele paternally die a few hours after birth (J:82266)
• mice inheriting the mutant allele paternally die a few hours after birth (J:82266)

respiratory system
• the respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis (J:82266)
• the respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis (J:82266)
• mice inheriting the mutant allele paternally gasp for air when born and turn cyanotic (J:82266)
• mice inheriting the mutant allele paternally gasp for air when born and turn cyanotic (J:82266)
• mice inheriting the mutant allele paternally exhibit hypoventilation resulting from a defective central respiratory drive (J:82266)
• mice inheriting the mutant allele paternally exhibit hypoventilation resulting from a defective central respiratory drive (J:82266)

cellular

homeostasis/metabolism
• in mutants with the paternally inherited allele (J:82266)
• in mutants with the paternally inherited allele (J:82266)
• in mutants with the paternally inherited allele (J:82266)
• in mutants with the paternally inherited allele (J:82266)

nervous system
• pups with abnormal breathing fail to generate rhythmic motor bursts from cervical or hypoglossal nerve roots in vitro or generate a severely irregular rhythmic motor output (J:82266)
• pups with abnormal breathing fail to generate rhythmic motor bursts from cervical or hypoglossal nerve roots in vitro or generate a severely irregular rhythmic motor output (J:82266)
• he respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis (J:82266)
• he respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis (J:82266)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:82266


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory