Phenotypes Associated with This Genotype

Genotype
MGI:2652685

• Allelic Composition: Slpi^tm1Nkw/Slpi^tm1Nkw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:82214 )

• B cell proliferation is increased in response to LPS-stimulation more so than in wild-type mice

• however, response to B cell receptor activation is normal

abnormal macrophage physiology ( J:82214 )

• macrophages produce more IL-6 than wild-type in response to LPS

increased interleukin-6 secretion ( J:82214 )

• mice exhibit a higher production of IL-6 after injection of LPS than wild-type mice

• macrophages produce more IL-6 than wild-type in response to LPS

increased susceptibility to endotoxin shock ( J:82214 )

• unlike wild-type mice, 76% of mice die following injection with LPS

• cecum ligation and puncture-induced sepsis results in higher lethality than in wild-type mice

hematopoietic system

increased B cell proliferation ( J:82214 )

• B cell proliferation is increased in response to LPS-stimulation more so than in wild-type mice

• however, response to B cell receptor activation is normal

abnormal macrophage physiology ( J:82214 )

• macrophages produce more IL-6 than wild-type in response to LPS

cellular

increased B cell proliferation ( J:82214 )

• B cell proliferation is increased in response to LPS-stimulation more so than in wild-type mice

• however, response to B cell receptor activation is normal