Phenotypes Associated with This Genotype

Genotype
MGI:2652493

• Allelic Composition: Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• thymocyte proliferation in response to TPA is impaired

• however, thymocyte proliferate in response to other stimuli

decreased T-helper 2 cell number ( J:172134 )

increased IgA level ( J:32561 )

• IgA levels are slightly increased following infection with N. brasiliensis

decreased IgE level ( J:32561 )

• IgE levels are lower than in wild-type mice following infection with N. brasiliensis

decreased IgG1 level ( J:32561 )

• IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice

increased IgG level ( J:32561 )

• IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis

abnormal T-helper 2 physiology ( J:32561 )

• mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis

hematopoietic system

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• thymocyte proliferation in response to TPA is impaired

• however, thymocyte proliferate in response to other stimuli

decreased T-helper 2 cell number ( J:172134 )

increased IgA level ( J:32561 )

• IgA levels are slightly increased following infection with N. brasiliensis

decreased IgE level ( J:32561 )

• IgE levels are lower than in wild-type mice following infection with N. brasiliensis

decreased IgG1 level ( J:32561 )

• IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice

increased IgG level ( J:32561 )

• IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis

abnormal T-helper 2 physiology ( J:32561 )

• mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis

cellular

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• thymocyte proliferation in response to TPA is impaired

• however, thymocyte proliferate in response to other stimuli