Phenotypes Associated with This Genotype

Genotype
MGI:2652092

• Allelic Composition: Dsp^tm1Efu/Dsp^tm1Efu; Tg(KRT14-cre)1Efu/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell adhesion ( J:67797 )

• mice have severe intracellular adhesion defects

integument

abnormal epidermal layer morphology ( J:67797 , J:73084 )

• large sections of the epidermis are missing and visible peeling occurs (J:67797)

• after mechanical stress, newborn mice show epithelial peeling (J:73084)

abnormal epidermis stratum basale morphology ( J:73084 )

• at E18.5, intracellular separation is pronounced

abnormal corneocyte envelope morphology ( J:73084 )

• cornified envelopes are bubble-bath like

abnormal epidermis stratum spinosum morphology ( J:73084 )

• at E18.5, intracellular separation is pronounced