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Phenotypes Associated with This Genotype
Genotype
MGI:2652044
Allelic
Composition		 Bmp15tm1Zuk/Bmp15tm1Zuk
Gdf9tm1Zuk/Gdf9tm1Zuk
Genetic
Background		 either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp15tm1Zuk mutation (0 available); any Bmp15 mutation (3 available)
Gdf9tm1Zuk mutation (0 available); any Gdf9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:69611 )
• loss of oocytes
abnormal zona pellucida morphology ( J:69611 )
• ovaries show increased zona pellucida remnants
abnormal ovary morphology ( J:69611 )
• proliferation of cells in the interstitium
impaired ovarian folliculogenesis ( J:69611 )
• block at the one layer follicle stage
ovary cyst ( J:69611 )
• uni- and bilateral ovarian cysts; only one cyst per ovary is present

endocrine/exocrine glands
abnormal ovary morphology ( J:69611 )
• proliferation of cells in the interstitium
impaired ovarian folliculogenesis ( J:69611 )
• block at the one layer follicle stage
ovary cyst ( J:69611 )
• uni- and bilateral ovarian cysts; only one cyst per ovary is present

cellular
absent oocytes ( J:69611 )
• loss of oocytes
abnormal zona pellucida morphology ( J:69611 )
• ovaries show increased zona pellucida remnants

growth/size/body
ovary cyst ( J:69611 )
• uni- and bilateral ovarian cysts; only one cyst per ovary is present

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory