Phenotypes Associated with This Genotype

Genotype
MGI:2652043

• Allelic Composition: Bmp15^tm1Zuk/Bmp15^tm1Zuk; Gdf9^tm1Zuk/Gdf9⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:69611 )

♀ • cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

♀ • superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

♀ • increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

♀ • ovaries show an increase in zona pellucida remnants

absent corpus luteum ( J:69611 )

♀

decreased mature ovarian follicle number ( J:69611 )

♀

absent cumulus expansion ( J:69611 )

♀ • failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

♀ • observe follicles with multiple oocytes

female infertility ( J:69611 )

♀ • Background Sensitivity: unlike on a mixed background where females are subfertile, females on the 129S7/SvEvBrd background completely fail to produce any offspring over a 6 month breeding period

endocrine/exocrine glands

absent corpus luteum ( J:69611 )

♀

decreased mature ovarian follicle number ( J:69611 )

♀

absent cumulus expansion ( J:69611 )

♀ • failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

♀ • observe follicles with multiple oocytes

cellular

abnormal oocyte morphology ( J:69611 )

♀ • cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

♀ • superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

♀ • increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

♀ • ovaries show an increase in zona pellucida remnants