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Phenotypes Associated with This Genotype
Genotype
MGI:2652042
Allelic
Composition
Bmp15tm1Zuk/Bmp15tm1Zuk
Gdf9tm1Zuk/Gdf9+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp15tm1Zuk mutation (0 available); any Bmp15 mutation (3 available)
Gdf9tm1Zuk mutation (0 available); any Gdf9 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice
• superovulated females sometimes contain large denuded oocytes
• increase in oocyte loss such that by 1 year of age, very few oocytes are present
• ovaries show an increase in zona pellucida remnants
• failure of cumulus expansion
• observe follicles with multiple oocytes
• Background Sensitivity: females on a mixed 129S7/SvEvBrd and C57BL/6J background give birth to litters of reduced size, less frequently and are not completely infertile as on a 129S7/SvEvBrd background
• average litter size is 3.67 (+/- 0.22) on mixed background

endocrine/exocrine glands
• failure of cumulus expansion
• observe follicles with multiple oocytes

cellular
• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice
• superovulated females sometimes contain large denuded oocytes
• increase in oocyte loss such that by 1 year of age, very few oocytes are present
• ovaries show an increase in zona pellucida remnants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory