reproductive system
• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice
• superovulated females sometimes contain large denuded oocytes
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• increase in oocyte loss such that by 1 year of age, very few oocytes are present
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• ovaries show an increase in zona pellucida remnants
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• failure of cumulus expansion
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• observe follicles with multiple oocytes
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• Background Sensitivity: females on a mixed 129S7/SvEvBrd and C57BL/6J background give birth to litters of reduced size, less frequently and are not completely infertile as on a 129S7/SvEvBrd background
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• average litter size is 3.67 (+/- 0.22) on mixed background
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endocrine/exocrine glands
• failure of cumulus expansion
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• observe follicles with multiple oocytes
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cellular
• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice
• superovulated females sometimes contain large denuded oocytes
|
• increase in oocyte loss such that by 1 year of age, very few oocytes are present
|
• ovaries show an increase in zona pellucida remnants
|