Mouse Genome Informatics
hm
    Lpltm1Sem/Lpltm1Sem
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• although born viable, all homozygotes die within 48 hrs of birth in the absence of pancreatic abnormalities

homeostasis/metabolism
• at 12 hrs after birth, homozygotes exhibit no detectable serum HDL cholesterol levels
• at 12 hrs after birth, homozygotes display significantly increased total serum cholesterol levels relative to wild-type controls
• at 12 hrs after birth, homozygotes display significantly increased serum phospholipid levels relative to wild-type controls
• at 12 hrs after birth, homozygotes display an extreme elevation of serum triglycerides (13,327 mg/dl) relative to wild-type controls
• at 12 hrs after birth, homozygotes display severe hyperlipidemia that is feeding-dependent

cardiovascular system
• hepatic congestion is consistently observed at autopsy
• pulmonary congestion is consistently observed at autopsy

respiratory system
• pulmonary congestion is consistently observed at autopsy
• observed at autopsy

liver/biliary system
• hepatic congestion is consistently observed at autopsy

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperlipoproteinemia, Type I 238600 J:25652