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Phenotypes Associated with This Genotype
Genotype
MGI:2651821
Allelic
Composition
Lpltm1Sem/Lpltm1Sem
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpltm1Sem mutation (0 available); any Lpl mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although born viable, all homozygotes die within 48 hrs of birth in the absence of pancreatic abnormalities

homeostasis/metabolism
• at 12 hrs after birth, homozygotes exhibit no detectable serum HDL cholesterol levels
• at 12 hrs after birth, homozygotes display significantly increased total serum cholesterol levels relative to wild-type controls
• at 12 hrs after birth, homozygotes display significantly increased serum phospholipid levels relative to wild-type controls
• at 12 hrs after birth, homozygotes display an extreme elevation of serum triglycerides (13,327 mg/dl) relative to wild-type controls
• at 12 hrs after birth, homozygotes display severe hyperlipidemia that is feeding-dependent

cardiovascular system
• hepatic congestion is consistently observed at autopsy
• pulmonary congestion is consistently observed at autopsy

respiratory system
• pulmonary congestion is consistently observed at autopsy
• observed at autopsy

liver/biliary system
• hepatic congestion is consistently observed at autopsy

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperlipoproteinemia, Type I 238600 J:25652


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory