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Phenotypes Associated with This Genotype
Genotype
MGI:2651807
Allelic
Composition
Lpltm1Bres/Lpl+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpltm1Bres mutation (0 available); any Lpl mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 42% reduction in the VLDL fractional catabolic rate
• a vitamin A fat tolerance test used to asses dietary fat (chylomicron) clearance indicates a delay in the clearance of chylomicrons and VLDL
• 10-30% modest elevation
• increase in cholesterol is in the VLDL fraction
• both in the fed and fasted state, triglyceride levels are 52-126% higher
• increase in triglycerides is in the VLDL fraction

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperlipoproteinemia, Type I 238600 J:30062


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory