Mouse Genome Informatics
ht
    Lpltm1Bres/Lpl+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 42% reduction in the VLDL fractional catabolic rate
• a vitamin A fat tolerance test used to asses dietary fat (chylomicron) clearance indicates a delay in the clearance of chylomicrons and VLDL
• 10-30% modest elevation
• increase in cholesterol is in the VLDL fraction
• both in the fed and fasted state, triglyceride levels are 52-126% higher
• increase in triglycerides is in the VLDL fraction

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperlipoproteinemia, Type I 238600 J:30062