Phenotypes Associated with This Genotype

Genotype
MGI:2651656

• Allelic Composition: Eif2s1^tm1Rjk/Eif2s1^tm1Rjk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:70004 )

• neonates died within 18 hours after birth

behavior/neurological

abnormal suckling behavior ( J:70004 )

• neonates did not nurse

endocrine/exocrine glands

decreased insulin secretion ( J:70004 )

• insulin level of neonatal pancreas was 35% of wild-type

homeostasis/metabolism

decreased insulin secretion ( J:70004 )

• insulin level of neonatal pancreas was 35% of wild-type

hypoglycemia ( J:70004 )

• severe hypoglycemia ensued 6-9 hours after birth

decreased circulating insulin level ( J:70004 )

• neonatal serum insulin level was 20% of wild-type