Phenotypes Associated with This Genotype

Genotype
MGI:2651586

• Allelic Composition: Dlg4^tm1Grnt/Dlg4^tm1Grnt
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77693 )

• reduced numbers of homozygotes relative to expected when tested after birth

growth/size/body

decreased body size ( J:77693 )

• 42% are initially runted but attain normal size by 6 weeks of age

nervous system

abnormal forebrain morphology ( J:109664 )

abnormal striatum morphology ( J:109664 )

• density of dendritic spines significantly reduced (by about 20%)

abnormal hippocampus pyramidal cell morphology ( J:109664 )

• density of dendritic spines of the apical dendrites of CA1 pyramidal neurons is about 40% higher between 60 and 80 micrometers from the cell body

• neuron morphology is otherwise normal

abnormal CNS synaptic transmission ( J:77693 )

enhanced long-term potentiation ( J:77693 , J:98903 )

• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation than in wildtype (J:98903)

enhanced paired-pulse facilitation ( J:77693 )

• at interpulse intervals of 20, 50,100, and 200 ms in CA1 pyramidal cells

behavior/neurological

abnormal spatial learning ( J:77693 , J:98903 )

• slower learning in a series of water maze tests (J:77693)

• homozygotes learn little in the spatial water maze test regardless of the amount of training received (J:98903)

abnormal pain threshold ( J:82335 )

• fail to develop thermal hyperalgesia and mechanical allodynia after chronic constriction injury of the sciatic nerve

allodynia ( J:82335 )

• cold allodynia severely attenuated relative to controls after chronic constriction injury of the sciatic nerve