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Phenotypes Associated with This Genotype
Genotype
MGI:2651379
Allelic
Composition
Itgb2tm1Bay/Itgb2tm1Bay
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2tm1Bay mutation (1 available); any Itgb2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)
• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)
• decreased inflammatory response to i.p. injection of thioglycollate showing decreased migration of neutrophils into the peritoneal cavity (J:13599)
• delayed rejection of cardiac transplants (J:13599)
• decreased inflammatory response to i.p. injection of thioglycollate showing decreased migration of neutrophils into the peritoneal cavity (J:13599)
• delayed rejection of cardiac transplants (J:13599)

hematopoietic system
• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)
• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)

integument
N
• Background Sensitivity: did not develop progressive dermatitis in the 129S7/SvEvBrd background (J:32126)
• Background Sensitivity: did not develop progressive dermatitis in the 129S7/SvEvBrd background (J:32126)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukocyte Adhesion Deficiency, Type I; LAD 116920 J:13599


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory