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Phenotypes Associated with This Genotype
Genotype
MGI:2451349
Allelic
Composition
Pax3Sp-d/Pax3Sp-d
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3Sp-d mutation (1 available); any Pax3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• 88.8% exhibit a neural tube defect
• seen in some mutants
• caudal rachischisis in all mutants
• mutants sometimes show exencephaly and spina bifida or exencephaly and a curly tail
• in 15 and 16 day old embryos, spinal gangalia of the lumbosacral region were reduced in size, residual or missing
• this phenotype is less severe than seen in Pax3Sp mutants
• dorsal roots are more disorganized and appear less frequently than in wild-type

limbs/digits/tail
• seen in some mutants

embryo
• 88.8% exhibit a neural tube defect
• seen in some mutants
• caudal rachischisis in all mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory