Mouse Genome Informatics
cn
    Sox9tm2Crm/Sox9tm2Crm
Tg(Prrx1-cre)1Cjt/0

involves: 129S/SvEv * C57BL/6J * SJL/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most die immediately in postnatal period from respiratory distress

limbs/digits/tail
• limb bud development arrested at E13.5
• absence of digit development

respiratory system
• animals die from respiratory distress

skeleton
• absence of bones in forelimbs and hindlimbs
• absence of cartilage in forelimbs and hindlimbs

embryogenesis
• limb bud development arrested at E13.5

cardiovascular system
• at E11.5 - E12.5, vascular patterning in the limbs is abnormal
• at E11.5 the axial artery is absent from the limbs
• at E12.5 metacarpal vascular centers are absent, instead limb vessels form a single wide center that spans the anterior-posterior axis of the limb
• at E12.5 avascular areas fail to develop

Mouse Models of Human Disease
OMIM IDRef(s)
Campomelic Dysplasia 114290 J:79879