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Phenotypes Associated with This Genotype
Genotype
MGI:2451166
Allelic
Composition
Csnk2a2tm1Dcs/Csnk2a2tm1Dcs
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk2a2tm1Dcs mutation (1 available); any Csnk2a2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• male homozygotes display a >70% reduction in the number of epididymal spermatozoa relative to controls
• oligospermia is partly attributed to failure of spermatozoa release and Sertoli cell phagocytosis
• mutant sperm flagella are occasionally bent or kinked
• starting at late step 9, elongating spermatids display deformation of the anterior sperm head
• as germ cells mature, many acrosomes become detached from the sperm nucleus and appear discontinuous in cross section
• elongating spermatids undergo normal chromatin condensation but display breaks or defects in the nuclear cap
• by the time of release into the epididymis, all surviving mutant spermatozoa fail to assume a hooked shape typical of wild-type spermatozoa, and appear round or ovoid
• in step 9, many elongating spermatids develop nuclei that are deformed and indented with the acrosome or sometimes with projections of the surrounding Sertoli cells
• by the time of release into the epididymis, some spontaneous decondensation of nuclear chromatin, similar to that induced by chemical agents, is observed
• starting at late step 9, elongating spermatids exhibit abnormalities of the acrosome-covered (anterior) head while posterior structures remain normal
• however, no abnormalities are detected up through step 8 round spermatids and early step 9, and spermatocytes, spermatogonia, and Sertoli cells appear normal
• mutant testes exhibit increased numbers of apoptotic germ cells, as well as a variety of apoptotic cell types including spermatocytes and round spermatids, as revealed by TUNEL staining
• male homozygotes exhibit occasional kinked or bent sperm flagella, resulting in uncoordinated sperm motility
• male, but not female, homozygotes are infertile

cellular
• male homozygotes display a >70% reduction in the number of epididymal spermatozoa relative to controls
• oligospermia is partly attributed to failure of spermatozoa release and Sertoli cell phagocytosis
• mutant sperm flagella are occasionally bent or kinked
• starting at late step 9, elongating spermatids display deformation of the anterior sperm head
• as germ cells mature, many acrosomes become detached from the sperm nucleus and appear discontinuous in cross section
• elongating spermatids undergo normal chromatin condensation but display breaks or defects in the nuclear cap
• by the time of release into the epididymis, all surviving mutant spermatozoa fail to assume a hooked shape typical of wild-type spermatozoa, and appear round or ovoid
• in step 9, many elongating spermatids develop nuclei that are deformed and indented with the acrosome or sometimes with projections of the surrounding Sertoli cells
• by the time of release into the epididymis, some spontaneous decondensation of nuclear chromatin, similar to that induced by chemical agents, is observed
• starting at late step 9, elongating spermatids exhibit abnormalities of the acrosome-covered (anterior) head while posterior structures remain normal
• however, no abnormalities are detected up through step 8 round spermatids and early step 9, and spermatocytes, spermatogonia, and Sertoli cells appear normal
• mutant testes exhibit increased numbers of apoptotic germ cells, as well as a variety of apoptotic cell types including spermatocytes and round spermatids, as revealed by TUNEL staining
• male homozygotes exhibit occasional kinked or bent sperm flagella, resulting in uncoordinated sperm motility

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
male infertility DOID:12336 J:57312


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory