Analysis Tools
mortality/aging
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• ~95% die within a day of birth
• the remaining 5% die within 5-10 days of birth
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limbs/digits/tail
polydactyly
(
J:30057
)
|
• ~33% exhbibited hind limb polydactyly, mixed background involving either C57BL/6J or MF1
• 1 mouse (of 14) was observed with hind limb polydactyly on the 129S/SvEv background
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renal/urinary system
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• bilateral renal dysplasia
• observed in both inbred and mixed backgrounds
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hydroureter
(
J:30057
)
|
• often accompanying renal dysplasia
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vision/eye
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• ~20% exhibited bilateral microphthalmia
• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia
• proportions observed on both inbred and mixed genetic backgrounds
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anophthalmia
(
J:30057
)
|
• ~60% exhibited bilateral anophthalmia
• ~20% exhibited unilateral anophthalmia in combination with unilateral microphthalmia
• proportions observed on both inbred and mixed genetic backgrounds
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skeleton
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• about 50% of mice display minor axial skeletal abnormalities
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• occasionally, membranous bones in cranial region are not fully developed
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• prevalent axial skeletal defect is failure of one or both of seventh rib pair to fuse to sternum, usually accompanied by absence of an obvious fourth sternebral ossification center
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craniofacial
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• occasionally, membranous bones in cranial region are not fully developed
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nervous system
exencephaly
(
J:30057
)
|
• exencephaly is observed in very low percentage of late stage or perinatal mutant mice
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