Phenotypes Associated with This Genotype

Genotype
MGI:2450731

• Allelic Composition: Apba1^tm1.1Sud/Apba1^tm1.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:81845 )

• mice exhibit slight but significant decrease in size compared to wild-type

nervous system

nervous system phenotype ( J:81845 )

N • mutants display normal paired pulse facilitation, use-dependent depression, posttetanic potentiation and long term potentiation

abnormal inhibitory postsynaptic currents ( J:81845 )

• inhibitory post synaptic currents (IPSCs) from CA1 pyramidal cells exhibit a large increase in paired pulse depression at short interstimulus intervals of <100 ms compared to wild-type

behavior/neurological

ataxia ( J:115573 )

• mutants display slightly increased ataxia index (area covered in 6 minutes/total distance traveled) compared to wild-type, indicating movement dysfunction