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Phenotypes Associated with This Genotype
Genotype
MGI:2449546
Allelic
Composition
F8tm2Kaz/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm2Kaz mutation (0 available); any F8 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• males exhibit hemophilia (J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized; however, no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)
• females exhibit normal fertility and pregnancy (J:36698)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
factor VIII deficiency DOID:12134 OMIM:134500
J:24941


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory