Mouse Genome Informatics
involves: 129S4/SvJae * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
• males exhibit hemophilia (J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized; however, no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)
• females exhibit normal fertility and pregnancy (J:36698)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

Mouse Models of Human Disease
Hemophilia A; HEMA 306700 J:24941