Mouse Genome Informatics
ot
    Btktm1Gsv/Y
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• decreased number of B220+ cells peripherally (J:35769)
• thymocyte and T cell numbers are unaffected (J:35769)
• mature IgMlowIgDhigh are nearly absent (J:35769)
• deficiency of CD5+ B cells in the peritoneum (J:35769)
• development through to large pre-B cell stage is normal (J:35769)
• transition from pre-B to immature B cell is impaired (J:35769)
• reduced IgM+IgD- to about 70% of normal numbers at 5 weeks of age (J:35769)
• significantly reduced calcium signaling in splenic B cells (J:94768)
• decreased lambda light chain usage (J:120989)
• IgG3 reduced 20% at 5 weeks of age (J:35769)
• reduced 50% at 5 weeks of age (J:35769)
• no response to T cell independent type II antigens (J:120989)

hematopoietic system
• decreased number of B220+ cells peripherally (J:35769)
• thymocyte and T cell numbers are unaffected (J:35769)
• mature IgMlowIgDhigh are nearly absent (J:35769)
• deficiency of CD5+ B cells in the peritoneum (J:35769)
• development through to large pre-B cell stage is normal (J:35769)
• transition from pre-B to immature B cell is impaired (J:35769)
• reduced IgM+IgD- to about 70% of normal numbers at 5 weeks of age (J:35769)
• significantly reduced calcium signaling in splenic B cells (J:94768)
• decreased lambda light chain usage (J:120989)
• IgG3 reduced 20% at 5 weeks of age (J:35769)
• reduced 50% at 5 weeks of age (J:35769)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:35769