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Phenotypes Associated with This Genotype
Genotype
MGI:2449181
Allelic
Composition
Ank1nb/Ank1nb
Genetic
Background
either: (involves: non-inbred stock) or (involves: C57BL/6) or (involves: WB/Re)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1nb mutation (2 available); any Ank1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• bright orange skin color at birth, fading with age

behavior/neurological
• after 6 months of age
• awkward, unbalanced gait develops after 6 months of age

cardiovascular system

growth/size/body

hematopoietic system
• the thymus is still present at 6 months of age
• normocytic hypochromic anemia
• becoming 8-10% of body weight

immune system
• the thymus is still present at 6 months of age
• becoming 8-10% of body weight

liver/biliary system
• appear in 57% of homozygotes after 6 months of age
• twice as frequent in females as in males
• jaundice at birth but no longer obvious as adults although obvious discoloration of urine, serum, and intestines persists

reproductive system

skeleton
• bone marrow hyperplasia

nervous system
• 50% cell loss after 6 months of age

homeostasis/metabolism
• although iron is quickly removed from the serum into erythrocytes, it does so to a lesser extent than normal and only 1/3 of the amount of iron normally seen in the femur is found there in 3 hours post iron incorporation

integument
• bright orange skin color at birth, fading with age

endocrine/exocrine glands
• the thymus is still present at 6 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Spherocytosis, Type 1; SPH1 182900 J:11441


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory