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Phenotypes Associated with This Genotype
involves: SELH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spta1sph-2Bc mutation (2 available); any Spta1 mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• about one-fourth survive to weaning and one-third of these to 6 months

• splenomegaly is seen in adults

hematopoietic system
• extramedullary hematopoiesis in the liver
• spherocytic, hemolytic anemia
• erythroid hyperplasia in the bone marrow
• abnormal forms of red blood cells include spherocytes, schistocytes, anisocytes, poikilocytes, erythroblasts, stipple cells, and elliptocytes (J:7048)
• absence of alpha-spectrin in the red cell membrane skeleton (J:7501)
• hematocrit is reduced by half
• hemoglobin level is reduced by more than half
• increased in white blood cell count
• increase in reticulocyte count (90% vs. 5-10% in controls)
• spleens are deep purple instead of red
• splenomegaly is seen in adults
• osmotic fragility is increased in red blood cells; red blood cells hemolyse at higher NaCl concentrations than controls

liver/biliary system
• jaundice appears after birth

• hyperbilirubinemia is seen as orange deposits in the liver and intestines

immune system
• increased in white blood cell count
• spleens are deep purple instead of red
• splenomegaly is seen in adults

• mice are pale at birth

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.20
The Jackson Laboratory