Mouse Genome Informatics
hm
    Spta1sph/Spta1sph
involves: C3H
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• none survive for more than 24 hours

hematopoietic system
• reticulocytes do not accumulate alpha spectrin in their membranes and do not synthesize detectable amounts of alpha spectrin

cardiovascular system
• livers show considerable congestion

homeostasis/metabolism

liver/biliary system
• livers are much darker than in control littermates
• livers show considerable congestion
• gradually acquire a yellow color during the first few hours of life

integument
• extremely pale at birth

Mouse Models of Human Disease
OMIM IDRef(s)
Spherocytosis, Type 1; SPH1 182900 J:12276
Spherocytosis, Type 3; SPH3 270970 J:12276