mortality/aging
• no transgenic males survive beyond birth
|
craniofacial
• males were described as showing foreshortened craniofacial features
|
embryo
• male embryos were typically smaller than normal littermates
|
growth/size/body
• male embryos were typically smaller than normal littermates
|
vision/eye
anophthalmia
(
J:76080
)
• observed in 83% of embryos age E9.5- E18.5
|
nervous system
• disorganized forebrain
|
exencephaly
(
J:76080
)
• observed in 83% of embryos age E9.5- E18.5
• cranial closure defects extended to a level caudal to the external ear indicating that in addition to forebrain and midbrain, the hindbrain neural folds failed to close normally
|