Phenotypes Associated with This Genotype

Genotype
MGI:2389585

• Allelic Composition: Insr^tm1Khn/Insr^tm1Khn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat pad morphology ( J:51266 )

• larger than normal fat depots in fat pads, including the perianal, subcutaneous and perigonadal fat pads

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:51266 )

N • normal serum cholesterol levels

N • normoglycemia, up to 11 months of age

N • normal glucose tolerance

N • normal concentrations of serum insulin

increased fatty acids level ( J:51266 )

• 20% elevation in serum free fatty acids (FFAs)

increased triglyceride level ( J:51266 )

• greater than70% elevated, observed from ages 4 to 11 months