About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2388265
Allelic
Composition
Adrb1tm1Bkk/Adrb1tm1Bkk
Adrb2tm1Bkk/Adrb2tm1Bkk
Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb1tm1Bkk mutation (1 available); any Adrb1 mutation (1 available)
Adrb2tm1Bkk mutation (1 available); any Adrb2 mutation (2 available)
Adrb3tm1Lowl mutation (1 available); any Adrb3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• obesity attributable to increased fat mass (J:79309)
• obesity attributable to increased fat mass (J:79309)
• interscapular brown adipose tissue (BAT) enlarged and pale (J:79309)
• BAT contained large cells with unilocular triglyceride deposits (J:79309)
• interscapular brown adipose tissue (BAT) enlarged and pale (J:79309)
• BAT contained large cells with unilocular triglyceride deposits (J:79309)

endocrine/exocrine glands
N
• normal thyroid hormone levels (J:79309)
• normal thyroid hormone levels (J:79309)

growth/size/body
• obesity attributable to increased fat mass (J:79309)
• obesity attributable to increased fat mass (J:79309)
• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat) (J:79309)
• normal food intake and normal physical activity on both normal and high fat diets were observed, however (J:79309)
• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat) (J:79309)
• normal food intake and normal physical activity on both normal and high fat diets were observed, however (J:79309)

homeostasis/metabolism
• normal body temperature under conventional housing conditions, but exposure to cold (22oC) produced rapid decline in core body temperature (J:79309)
• failure of diet-induced thermogenesis (J:79309)
• normal body temperature under conventional housing conditions, but exposure to cold (22oC) produced rapid decline in core body temperature (J:79309)
• failure of diet-induced thermogenesis (J:79309)
• increased leptin levels (J:79309)
• increased leptin levels (J:79309)
• reduced metabolic rate, measured by O2 consumption (J:79309)
• isoproterenol exposure failed to increase O2 consumption (J:79309)
• reduced metabolic rate, measured by O2 consumption (J:79309)
• isoproterenol exposure failed to increase O2 consumption (J:79309)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:79309


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory