Mouse Genome Informatics
cx
    Adrb1tm1Bkk/Adrb1tm1Bkk
Adrb2tm1Bkk/Adrb2tm1Bkk
Adrb3tm1Lowl/Adrb3tm1Lowl

involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• obesity attributable to increased fat mass
• interscapular brown adipose tissue (BAT) enlarged and pale
• BAT contained large cells with unilocular triglyceride deposits

endocrine/exocrine glands
N
• normal thyroid hormone levels (J:79309)

growth/size
• obesity attributable to increased fat mass
• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat)
• normal food intake and normal physical activity on both normal and high fat diets were observed, however

homeostasis/metabolism
• failure of diet-induced thermogenesis
• normal body temperature under conventional housing conditions, but exposure to cold (22oC) produced rapid decline in core body temperature
• increased leptin levels
• reduced metabolic rate, measured by O2 consumption
• isoproterenol exposure failed to increase O2 consumption

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:79309