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Phenotypes Associated with This Genotype
Genotype
MGI:2388265
Allelic
Composition
Adrb1tm1Bkk/Adrb1tm1Bkk
Adrb2tm1Bkk/Adrb2tm1Bkk
Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adrb1tm1Bkk mutation (1 available); any Adrb1 mutation (4 available)
Adrb2tm1Bkk mutation (1 available); any Adrb2 mutation (14 available)
Adrb3tm1Lowl mutation (1 available); any Adrb3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• obesity attributable to increased fat mass
• interscapular brown adipose tissue (BAT) enlarged and pale
• BAT contained large cells with unilocular triglyceride deposits

endocrine/exocrine glands
N
• normal thyroid hormone levels

growth/size/body
• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat)
• normal food intake and normal physical activity on both normal and high fat diets were observed, however

homeostasis/metabolism
• normal body temperature under conventional housing conditions, but exposure to cold (22oC) produced rapid decline in core body temperature
• failure of diet-induced thermogenesis
• increased leptin levels
• reduced metabolic rate, measured by O2 consumption
• isoproterenol exposure failed to increase O2 consumption

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:79309


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory