homeostasis/metabolism
• increased sensitivity to the drugs ivermectin and vinblastine
|
• rate of rhodamine efflux from hematopoietic progenitor cells is diminished
|
cardiovascular system
• mutants given oral subtoxic doses of livermectin show 90-fold higher levels of the drug in the brain than in wild-type after 24 hours, indicating impaired blood-brain barrier function
|
nervous system
• mutants given oral subtoxic doses of livermectin show 90-fold higher levels of the drug in the brain than in wild-type after 24 hours, indicating impaired blood-brain barrier function
|