Phenotypes Associated with This Genotype

Genotype
MGI:2386648

• Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:18554 )

• increased sensitivity to the drugs ivermectin and vinblastine

abnormal xenobiotic pharmacokinetics ( J:39804 )

• rate of rhodamine efflux from hematopoietic progenitor cells is diminished

cardiovascular system

impaired blood-brain barrier function ( J:18554 )

• mutants given oral subtoxic doses of livermectin show 90-fold higher levels of the drug in the brain than in wild-type after 24 hours, indicating impaired blood-brain barrier function

nervous system

impaired blood-brain barrier function ( J:18554 )

• mutants given oral subtoxic doses of livermectin show 90-fold higher levels of the drug in the brain than in wild-type after 24 hours, indicating impaired blood-brain barrier function