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Phenotypes Associated with This Genotype
Genotype
MGI:2386447
Allelic
Composition
Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Xpatm1Hvs/Xpatm1Hvs
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc2tm2(ERCC2)Jhjh mutation (0 available); any Ercc2 mutation (5 available)
Xpatm1Hvs mutation (2 available); any Xpa mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• incomplete penetrance (J:76608)
• incomplete penetrance (J:76608)
• surviving mice dead by 22 days of age (J:76608)
• surviving mice dead by 22 days of age (J:76608)

behavior/neurological

growth/size/body
• develop extreme cachexia by 2-3 weeks of age (J:76608)
• develop extreme cachexia by 2-3 weeks of age (J:76608)
• exhibit a retarded but steady growth until 1.5 weeks, but fail to gain weight after 2-3 weeks (J:76608)
• exhibit a retarded but steady growth until 1.5 weeks, but fail to gain weight after 2-3 weeks (J:76608)

skeleton

adipose tissue
• complete absence of body fat, including subcutaneous fat (J:76608)
• complete absence of body fat, including subcutaneous fat (J:76608)

cellular
• seen in MEFs (J:76608)
• seen in MEFs (J:76608)

integument
• severe dilation of hair follicles (J:76608)
• severe dilation of hair follicles (J:76608)
• excessive epidermal hyperkeratosis (J:76608)
• excessive epidermal hyperkeratosis (J:76608)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory