Mouse Genome Informatics
cx
    Tg(APOB)11Rub/0
Tg(UcpDta)1Kz/0

involves: C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism
• males on a Western diet exhibit increased fasting plasma insulin levels
• however, fasting plasma glucose and free fatty acid levels do not vary from controls
• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose
• males display a human-like dyslipidemia
• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides
• males exhibit increased apolipoprotein B (apoB) secretion rates
• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations
• LDL cholesterol is increased relative to Tg(APOB)11Rub mice
• males on a Western diet exhibit increased fasting plasma triglyceride concentrations
• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:78211