Phenotypes Associated with This Genotype

Genotype
MGI:2385449

• Allelic Composition: Mycn^tm1Nagy/Mycn^tm2.1Nagy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:67930 )

• animals die at birth

cardiovascular system

abnormal angiogenesis ( J:67930 )

• deficiency of angiogenesis in yolk sac

absent vitelline blood vessels ( J:67930 )

thin myocardium ( J:67930 )

• thin, compact myocardium

embryo

absent vitelline blood vessels ( J:67930 )

decreased embryo size ( J:67930 )

• smaller size apparent by E12.5

pale yolk sac ( J:67930 )

• apparent by E15.5

growth/size/body

decreased embryo size ( J:67930 )

• smaller size apparent by E12.5

respiratory system

abnormal lung development ( J:67930 )

• incomplete lung development

respiratory failure ( J:67930 )

• animals do not breathe after birth

skeleton

abnormal vertebrae morphology ( J:67930 )

• abnormal vertebral column, reduced in length by 40%

abnormal vertebral body development ( J:67930 )

• split ossification of vertebral bodies

small vertebral body ( J:67930 )

• reduced size of vertebral bodies and split ossification

vertebral fusion ( J:67930 )

muscle

thin myocardium ( J:67930 )

• thin, compact myocardium