Phenotypes Associated with This Genotype

Genotype
MGI:2183371

• Allelic Composition: Msh3^tm1Rak/Msh3^tm1Rak; Msh6^tm1Rak/Msh6^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:60604 )

• 50% moribund or morbid by 5 - 6 months of age

neoplasm

increased gastrointestinal tumor incidence ( J:60604 )

• mice develop predominantly GI tumors

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 12 of 16 mice

increased lymphoma incidence ( J:60604 )

• non-Hodgkin's lymphomas

cellular

abnormal mismatch repair ( J:60604 )

• cells lack mismatch repair

homeostasis/metabolism

abnormal mismatch repair ( J:60604 )

• cells lack mismatch repair

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:60604 )

• mice develop predominantly GI tumors

increased intestinal adenocarcinoma incidence ( J:60604 )

• in 12 of 16 mice