Phenotypes Associated with This Genotype

Genotype
MGI:2183174

• Allelic Composition: Bmp4^tm1Blh/Bmp4^tm1Blh
• Genetic Background: B6.129S2-Bmp4^tm1Blh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:28717 )

• none survive beyond the egg cylinder stage

embryo

failure of primitive streak formation ( J:28717 )

• absence of organized primitive streak

abnormal visceral yolk sac morphology ( J:28717 )

absent visceral yolk sac blood islands ( J:28717 )

• there is a relative paucity of blood islands containing red blood cells in the visceral yolk sac

abnormal extraembryonic mesoderm development ( J:28717 )

• hypoplastic extraembryonic mesoderm: small amount can be distinguished

hematopoietic system

decreased erythrocyte cell number ( J:28717 )

• few red blood cells are found in the heart, dorsal aorta, and vessels of an E8.5 embryo