About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2183043
Allelic
Composition
Adatm1Mw/Adatm1Mw
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation (3 available); any Ada mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hepatocyte abnormalities in Adatm1Mw/Adatm1Mw mice

cellular
• enlarged hepatocytes with karyomegaly as early as E16.5
• evident at E17.5

mortality/aging
• animals die at birth or shortly thereafter
• only 10% born with beating hearts, but these animals did not move

growth/size/body
• 15% smaller than littermates

homeostasis/metabolism
• pups born with beating hearts remained cyanotic until death a few hours later
• elevated levels of hepatocellular enzymes, aspartate aminotransferase (66%) and alanine aminotransferase (56%)
• dATP levels in fetal blood are elevated 2000-fold while ATP levels are decreased slightly

immune system
• decreased numbers of mature T lymphocytes

liver/biliary system
• livers have disorganized hepatic plates, resulting in isolated packets of cells
• evident at E17.5
• morphological changes in hepatocytes are seen as early as E16.5, including enlarged hepatocytes with karyomegaly, irregularly shaped nuclear envelopes, and a decrease in heterochromatin
• cytoplasm of hepatocytes has decreased amounts of glycogen and increased volume of rough ER
• hepatocytes lose their normal polyhedral shape and become round
• enlarged hepatocytes with karyomegaly as early as E16.5
• decrease in numbers of hepatocytes per lobule
• 29% smaller than littermates

hematopoietic system
• decreased numbers of mature T lymphocytes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory