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Phenotypes Associated with This Genotype
Genotype
MGI:2183031
Allelic
Composition
Crybb2Phil/Crybb2Phil
Genetic
Background
Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crybb2Phil mutation (1 available); any Crybb2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dry weight is markedly reduced
• while normal lenses maintain a high potassium--low sodium content, in mutant lenses this ratio is reversed, beginning at about 15 days; appears to be due to a change in membrane permeability rather than to a defect in the cation pump mechanism
• visible to the naked eye at 5 to 6 weeks after birth, faint anterior opacity is visible at 15 days of age by slit lamp observation
• at 45 days, there is total dense nuclear opacity along with striking anterior and posterior subcapsular opacity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 3 multiple types DOID:0110269 OMIM:601547
J:11126


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory