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Phenotypes Associated with This Genotype
Genotype
MGI:2182802
Allelic
Composition
Apctm1Mmt/Apc+
Smad4tm1Mmt/Smad4+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Mmt mutation (0 available); any Apc mutation (59 available)
Smad4tm1Mmt mutation (0 available); any Smad4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• polyps in small and large intestine develop into malignant adenocarcinomas, beginning at about 14 weeks

endocrine/exocrine glands
• adenocarcinomas found in ampullary region of the pancreatic duct, incomplete penetrance

mortality/aging
• most mutants become moribund before 14-20 weeks and often die of intussusception of the small intestine

neoplasm
• polyps in small and large intestine develop into malignant adenocarcinomas, beginning at about 14 weeks
• adenocarcinomas found in ampullary region of the pancreatic duct, incomplete penetrance

integument
• in 53% of mice older than 10 weeks, skin epidermoid cysts found in left axillary region and/or ventral side of the neck


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory